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Accumulating evidence suggests that chronic drug and alcohol abuse is associated with accumbens of conscious freely Adipex moving Adipex rats. A series of amphetamine derivatives including phentermine chlorphentermine fenfluramine and PHEN/FEN (1:1 ratio) were infused Adipex Adipex locally into the accumbens via reverse-dialysis (1 10 100 M) or injected systemically (1 mg/kg ip). Dialysate samples were assayed for dopamine (DA) and serotonin (5-HT) by high-performance liquid chromatography with electrochemical detection. When infused locally Adipex Adipex phentermine preferentially increased extracellular DA whereas fenfluramine selectively Adipex increased extracellular Adipex 5-HT. Local administration of chlorphentermine or the PHEN/FEN mixture caused parallel elevations of both transmitters. Analogous results Adipex were obtained Adipex when the Adipex drugs were injected systemically. Phentermine Adipex stimulated robust locomotor activity in mice whereas chlorphentermine and fenfluramine Adipex did not. PHEN/FEN caused modest locomotor stimulation after a low dose Adipex Adipex Adipex but had no effect at the highest dose. Accumulating evidence suggests that chronic drug Adipex and alcohol abuse is associated Adipex with accumbens of conscious freely moving rats.

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